Lupanin 17-hidroksilaza (citohrom c)
Lupanin 17-hidroksilaza (citohrom c) (EC 1.17.2.2, lupaninska dehidrogenaza (citohrom c)) je enzim sa sistematskim imenom lupanin:citohrom c-oksidoreduktaza (17-hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Lupanin 17-hidroksilaza (citohrom c) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.17.2.2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- lupanin + 2 fericitohrom c + H2O 17-hidroksilupanin + 2 ferocitohrom c + 2 H+
Ovaj enzim izolovan iz Pseudomonas putida sadrži heme c. Za njegovo dejstvo je neophodan pirolohinolin hinon (PQQ).
Reference uredi
- ↑ Hopper, D.J., Rogozinski, J. and Toczko, M. (1991). „Lupanine hydroxylase, a quinocytochrome c from an alkaloid-degrading Pseudomonas sp”. Biochem. J. 279: 105-109. PMID 1656935.
- ↑ Hopper, D.J. and Kaderbhai, M.A. (2003). „The quinohaemoprotein lupanine hydroxylase from Pseudomonas putida”. Biochim. Biophys. Acta 1647: 110-115. PMID 12686118.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.