Lupan-3beta,20-diolna sintaza
Lupan-3beta,20-diolna sintaza (EC 4.2.1.128, LUP1 (gen)) je enzim sa sistematskim imenom (3S)-2,3-epoksi-2,3-dihidroskvalen hidrolijaza (formira lupan-3beta,20-diol).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Lupan-3beta,20-diolna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.128 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- lupan-3beta,20-diol (3S)-2,3-epoksi-2,3-dihidroskvalen + H2O
Ovaj reakcija se odvija u reverznom smeru.
Reference
uredi- ↑ Segura, M.J., Meyer, M.M. and Matsuda, S.P. (2000). „Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol”. Org. Lett. 2: 2257-2259. PMID 10930257.
- ↑ Kushiro, T., Hoshino, M., Tsutsumi, T., Kawai, K., Shiro, M., Shibuya, M. and Ebizuka, Y. (2006). „Stereochemical course in water addition during LUP1-catalyzed triterpene cyclization”. Org. Lett. 8: 5589-5592. PMID 17107079.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.