Lovastatin nonaketid sintaza
Lovastatin nonaketid sintaza (EC 2.3.1.161) je enzim sa sistematskim imenom acil-KoA:malonil-KoA C-aciltransferaza (dekarboksilacija, oksoacil- i enoilna redukcija, tioestarska hidroliza).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Lovastatin nonaketid sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.161 | ||||||||
| CAS broj | 235426-97-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- acetil-KoA + 8 malonil-KoA + 11 NADPH + 10 H+ + S-adenozil-L-metionin dihidromonacolin L + 9 KoA + 8 CO2 + 11 NADP+ + S-adenozil-L-homocistein + 6H2O
Mikrobni enzim je multifunkcionalni protein koji katalizuje mnoge reakcije formanja lanca enzima EC 2.3.1.85, masno-kiselinske sintaza, kao i reduktivne metilacije i Dils-Alderove reakcije.
Reference uredi
- ↑ Auclair, K., Sutherland, A., Kennedy, J., Witter, D.J., van der Heever, J.P., Hutchinson, C.R. and Vederas, J.C. (2000). „Lovastatin nonaketide synthase catalyses an intramolecular Diels-Alder reaction of a substrate analogue”. J. Am. Chem. Soc. 122: 11519-11520.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.