Lipopolisaharid N-acetilmanozaminouronosyltransferaza
Lipopolisaharid N-acetilmanozaminouronosyltransferaza (EC 2.4.1.180, ManNAcA transferaza, uridin difosfoacetilmanozaminuronat-acetilglukozaminilpirofosforilundekaprenol acetilmanozaminuronoziltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-beta-D-manozaminouronat:lipid I N-acetil-beta-D-manozaminouronosiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Lipopolisaharid N-acetilmanozaminouronosyltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.180 | ||||||||
| CAS broj | 113478-30-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-N-acetil-beta-D-manozaminouronat + N-acetil-alfa-D-glukozaminil-difosfo-ditrans,oktacis-undekaprenol UDP + N-acetil-beta-D-manozaminouronil-(1->4)-N-acetil-alfa-D-glukozaminil-difosfo-ditrans,oktacis-undekaprenol
Ovaj enzim učestvuje u biosintezi rasprostranjenog antigena kod Enterobakterijaceae.
Reference
uredi- ↑ Barr, K., Ward, S., Meier-Dieter, U., Mayer, H. and Rick, P.D. (1988). „Characterization of an Escherichia coli rff mutant defective in transfer of N-acetylmannosaminuronic acid (ManNAcA) from UDP-ManNAcA to a lipid-linked intermediate involved in enterobacterial common antigen synthesis”. J. Bacteriol. 170: 228-233. PMID 3275612.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.