Linoleat diol sintaza
Linoleat diol sintaza (EC 1.13.11.44, linoleatna (8R)-dioksigenaza) je enzim sa sistematskim imenom linoleat:kiseonik 7S,8S-oksidoreduktaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Linoleat diol sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.44 | ||||||||
| CAS broj | 143793-22-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- linoleat + O2 (9Z,12Z)-(7S,8S)-dihidroksioktadeka-9,12-dienoat
Oleat i linolenat su takođe supstrati.
Reference uredi
- ↑ Brodowsky, I.D., Hamberg, M. and Oliw, E.H. (1992). „A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid”. J. Biol. Chem. 267: 14738-14745. PMID 1634517.
- ↑ Hamberg, M., Zhang, L.-Y., Brodowsky, I.D. and Oliw, E.H. (1994). „Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions”. Arch. Biochem. Biophys. 309: 77-80. PMID 8117115.
- ↑ Hornsten, L., Su, C., Osbourn, A.E., Garosi, P., Hellman, U., Wernstedt, C. and Oliw, E.H. (1999). „Cloning of linoleate diol synthase reveals homology with prostaglandin H synthases”. J. Biol. Chem. 274: 28219-28224. PMID 10497176.
- ↑ Oliw, E.H., Su, C., Skogstrom, T. and Benthin, G. (1998). „Analysis of novel hydroperoxides and other metabolites of oleic, linoleic and linolenic acids by liquid chromatography-mass spectrometry with ion trap MSn”. Lipids 33: 843-852. PMID 9778131.
- ↑ Su, C. and Oliw, E.H. (1996). „Purification and characterization of linoleate 8-dioxygenase from the fungus Gaeumannomyces graminis as a novel hemoprotein”. J. Biol. Chem. 271: 14112-14118. PMID 8662736.
- ↑ Su, C., Sahlin, M. and Oliw, E.H. (1998). „A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities”. J. Biol. Chem. 273: 20744-20751. PMID 9694817.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.