Limonen-1,2-diol dehidrogenaza
Limonen-1,2-diol dehidrogenaza (EC 1.1.1.297, NAD+-zavisna limonen-1,2-diolna dehidrogenaza) je enzim sa sistematskim imenom ment-8-en-1,2-diol:NAD+ oksidoreduktaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Limonen-1,2-diol dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.297 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ment-8-en-1,2-diol + NAD+ 1-hidroksiment-8-en-2-on + NADH + H+ (generalna reakcija)
- (1) (1S,2S,4R)-ment-8-en-1,2-diol + NAD+ (1S,4R)-1-hidroksiment-8-en-2-on + NADH + H+
- (2) (1R,2R,4S)-ment-8-en-1,2-diol + NAD+ (1R,4S)-1-hidroksiment-8-en-2-on + NADH + H+
Enzim iz gram-pozitivne bakterije Rhodococcus eritropolis DCL14 može da koristi (1S,2S,4R)- i (1R,2R,4S)-ment-8-en-1,2-diol kao supstrat. Aktivnost je viša sa (1S,2S,4R)-ment-8-en-1,2-diolom kao supstratom.
Reference
uredi- ↑ van der Werf, M.J., Swarts, H.J. and de Bont, J.A. (1999). „Rhodococcus erythropolis DCL14 contains a novel degradation pathway for limonene”. Appl. Environ. Microbiol. 65: 2092-2102. PMID 10224006.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.