Levopimaradienska sintaza
Levopimaradienska sintaza (EC 4.2.3.32, PtTPS-LAS, LPS, kopalil-difosfat difosfat-lijaza (formira abieta-8(14),12-dien)) je enzim sa sistematskim imenom (+)-copalil-difosfat difosfat-lijaza (formira abieta-8(14),12-dien).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Levopimaradienska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.32 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (+)-kopalil difosfat abieta-8(14),12-dien + difosfat
U ginku, ovaj enzim katalizuje inicijalnu ciklizaciju u biosintezi ginkolida.
Reference uredi
- ↑ Schepmann, H.G., Pang, J. and Matsuda, S.P. (2001). „Cloning and characterization of Ginkgo biloba levopimaradiene synthase which catalyzes the first committed step in ginkgolide biosynthesis”. Arch. Biochem. Biophys. 392: 263-269. PMID 11488601.
- ↑ Ro, D.K. and Bohlmann, J. (2006). „Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)”. Phytochemistry 67: 1572-1578. PMID 16497345.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.