Leukocijanidin oksigenaza
Leukocijanidin oksigenaza (EC 1.14.11.19, antocijanidinska sintaza) je enzim sa sistematskim imenom leukocijanidin,2-oksoglutarat:kiseonik oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Leukocijanidin oksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.11.19 | ||||||||
| CAS broj | 180984-01-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- leuocijanidin + 2-oksoglutarat + O2 cis- i trans-dihidrokvercetini + sukcinat + CO2 + 2H2O
Za rad ovog enzima se neophodni Fe2+ i askorbat. On učestvuje u putu kojim mnoge cvetne biljke formiraju antocijanin (glikozilisane antocijandinske) cvetne pigmente.
Reference uredi
- ↑ Saito, K., Kobayashi, M., Gong, Z., Tanaka, Y. and Yamazaki, M. (1999). „Direct evidence for anthocyanidin synthase as a 2-oxoglutarate-dependent oxygenase: molecular cloning and functional expression of cDNA from a red forma of Perilla frutescens”. Plant J. 17: 181-190. PMID 10074715.
- ↑ Turnbull, J.J., Sobey, W.J., Aplin, R.T., Hassan, A., Firmin, J.L., Schofield, C.J. and Prescott, A.G. (2000). „Are anthocyanidins the immediate products of anthocyanidin synthase?”. Chem. Commun.: 2473-2474.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.