Leišmanolizin
Leišmanolizin (EC 3.4.24.36, promastigotna površinska endopeptidaza, glikoprotein gp63, Leishmania metaloproteinaza, površinska kiselinska proteinaza, promastigotna površinska proteaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Leišmanolizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.36 | ||||||||
| CAS broj | 161052-06-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Preferentno dejstvo na supstrate sa hidrofobnim ostacima u P1 i P1' i baznim ostacima u P2' i P3'. Modelni nanapeptid se razlaže na -Ala-Tyr-Leu-Lys-Lys-
Ovaj za membranu vezani glikoprotein je prisutan tripanozomskim vrstama Leishmania protozoans.
Reference
uredi- ↑ Button, L.L. and McMaster, W.R. (1988). „Molecular cloning of the major surface antigen of Leishmania”. J. Exp. Med. 167: 724-729. PMID 3346625.
- ↑ Bouvier, J., Cordier, C., Vogel, H., Reichelt, R. and Etges, R. (1989). „Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidase”. Mol. Biochem. Parasitol. 37: 235-246. PMID 2608099.
- ↑ Chaudhuri, G., Chaudhuri, M., Pan, A. and Chang, K.-P. (1989). „Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages”. J. Biol. Chem. 264: 7483-7489. PMID 2708373.
- ↑ Bouvier, J., Schneider, P., Etges, R. and Bordier, C. (1990). „Peptide substrate specificity of the membrane-bound metalloprotease of Leishmania”. Biochemistry 29: 10113-10119. PMID 2271643.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.