Laktoza sintaza
Laktoza sintaza (EC 2.4.1.22, UDP-galaktoza glukoza galaktoziltransferaza, N-acetillaktozaminska sintaza, uridin difosfogalaktoza-glukoza galaktoziltransferaza, laktozna sintetaza, UDP-galaktoza:D-glukoza 4-beta-D-galaktotransferaza, UDP-galaktoza:D-glukoza 4-beta-D-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:D-glukoza 4-beta-D-galaktoziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Laktoza sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Laktoza sintaza monomer, Bos taurus + alpha-lactalbumin, Mus musculus | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.4.1.22 | ||||||||
| CAS broj | 2604493 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ovaj enzim je kompleks dva proteina, A i B. U odsustvu B proteina (alfa-laktalbumina), ovaj enzim katalizuje transfer galaktoze sa UDP-alfa-D-galaktoze na N-acetilglukozamin (EC 2.4.1.90, N-acetilaktozamin sintaza).
Reference uredi
- ↑ Fitzgerald, D.K., Brodbeck, U., Kiyosawa, I., Mawal, R., Colvin, B. and Ebner, K.E. (1970). „α-Lactalbumin and the lactose synthetase reaction”. J. Biol. Chem. 245: 2103-2108. PMID 5440844.
- ↑ Hill, R.L. and Brew, K. (1975). „Lactose synthetase”. Adv. Enzymol. Relat. Areas Mol. Biol. 43: 411-490. PMID 812340.
- ↑ Watkins, W.M. and Hassid, W.Z. (1962). „The synthesis of lactose by particulate enzyme preparations from guinea pig and bovine mammary glands”. J. Biol. Chem. 237: 1432-1440. PMID 14005251.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.