Laktoil-KoA dehidrataza
Laktoil-KoA dehidrataza (EC 4.2.1.54, laktoil koenzim A dehidrataza, laktil-koenzim A dehidraza, laktil KoA dehidrataza, akrilil koenzim A hidrataza, laktoil-KoA hidrolijaza) je enzim sa sistematskim imenom (R)-laktoil-KoA hidrolijaza (formira acriloil-KoA).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Laktoil-KoA dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.54 | ||||||||
| CAS broj | 2604882 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (R)-laktoil-KoA akriloil-KoA + H2O
Bakterijski enzim učestvuje u propanoatnoj fermentaciji.
Reference uredi
- ↑ Baldwin, R.L., Wood, W.A. and Emery, R.S. (1965). „Lactate metabolism by Peptostreptococcus elsdenii: evidence for lactyl coenzyme a dehydrase”. Biochim. Biophys. Acta 97: 202-213. PMID 14292829.
- ↑ Schweiger, G. and Buckel, W. (1984). „On the dehydration of (R)-lactate in the fermentation of alanine to propionate by Clostridium propionicum”. FEBS Lett 171: 79-84. PMID 6586495.
- ↑ Kuchta, R.D. and Abeles, R.H. (1985). „Lactate reduction in Clostridium propionicum. Purification and properties of lactyl-CoA dehydratase”. J. Biol. Chem. 260: 13181-13189. PMID 4055736.
- ↑ Kuchta, R.D., Hanson, G.R., Holmquist, B. and Abeles, R.H. (1986). „Fe-S centers in lactyl-CoA dehydratase”. Biochemistry 25: 7301-7307. PMID 3026450.
- ↑ Hofmeister, A.E. and Buckel, W. (1992). „(R)-lactyl-CoA dehydratase from Clostridium propionicum. Stereochemistry of the dehydration of (R)-2-hydroxybutyryl-CoA to crotonyl-CoA”. Eur. J. Biochem. 206: 547-552. PMID 1597194.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.