Leukotrien-C4 sintaza
(Preusmjereno sa stranice LTC4 synthetase)
Leukotrien-C4 sintaza (EC 4.4.1.20, leukotrien C4 sintetaza, LTC4 sintaza, LTC4 sintetaza, leukotrien A4:glutation S-leukotrieniltransferaza, (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoksiikosa-7,9,11,14-tetraenoat:glutation leukotrien-transferaza (otvaranje epoksidnog prstena), (7E,9E,11Z,14Z)-(5S,6R)-6-(glutation-S-il)-5-hidroksiikosa-7,9,11,14-tetraenoat glutation-lijaza (formira epoksid)) je enzim sa sistematskim imenom leukotrien-C4 glutation-lijaza (formira leukotrien-A4).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Leukotrien-C4 sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.4.1.20 | ||||||||
| CAS broj | 90698-32-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- leukotrien C4 leukotrien A4 + glutation
Ovaj reakcija se odvija u smeru adicije.
Reference
uredi- ↑ Bach, M.K., Brashler, J.R. and Morton, D.R., Jr. (1984). „Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase”. Arch. Biochem. Biophys. 230: 455-465. PMID 6324687.
- ↑ Shimizu, T. (1988). „Enzymes functional in the syntheses of leukotrienes and related compounds”. Int. J. Biochem. 20: 661-666. PMID 2846379.
- ↑ Lam, B.K. and Austen, K.F. (2002). „Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes”. Prostaglandins Other Lipid Mediat. 68-69: 511-520. PMID 12432940.
- ↑ Christmas, P., Weber, B.M., McKee, M., Brown, D. and Soberman, R.J. (2002). „Membrane localization and topology of leukotriene C4 synthase”. J. Biol. Chem. 277: 28902-28908. PMID 12023288.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.