Saharopepsin
(Preusmjereno sa stranice Kvašćana proteinaza A)
Saharopepsin (EC 3.4.23.25, kvašćana endopeptidaza A, Saccharomyces aspartinska proteinaza, aspartinska proteinaza yscA, proteinaza A, proteinaza yscA, kvašćana proteinaza A, Saccharomyces cerevisiae aspartinska proteinaza A, kvašćana proteinaza A, PRA) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Saharopepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.25 | ||||||||
| CAS broj | 37228-80-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Hidroliza proteina sa širokom specifičnošću za peptidne veze. Razlaže se -Leu-Leu-Val-Tyr veza u sintetičnim supstratime. Ne dolazi do reakcije na estrima Tyr ili Arg
Ovaj enzim je prisutan u vakuolama pekarskog kvasca (Saccharomyces cerevisiae).
Reference
uredi- ↑ Hata, T., Hayashi, R. and Dot, E. (1967). „Purification of yeast proteinases. Part III. Isolation and physicochemical properties of yeast proteinase A and C”. Agric. Biol. Chem. 31: 357-367.
- ↑ Meussdoerffer, F., Tortora, P. and Holzer, H. (1980). „Purification and properties of proteinase A from yeast”. J. Biol. Chem. 255: 12087-12093. PMID 7002931.
- ↑ Ammerer, G., Hunter, C.P., Rothman, J.H., Saari, G.C., Valls, L.A. and Stevens, T.H. (1987). „PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors”. Mol. Cell. Biol. 6: 2490-2499. PMID 3023936.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.