Kortikosteroidna izomeraza bočnog lanaca
Kortikosteroidna izomeraza bočnog lanaca (EC 5.3.1.21) je enzim sa sistematskim imenom 11-dezoksikortikosteron aldoza-ketoza-izomeraza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kortikosteroidna izomeraza bočnog lanaca | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.3.1.21 | ||||||||
| CAS broj | 75139-73-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 11-dezoksikortikosteron 20-hidroksi-3-oksopregn-4-en-21-al
Epimerizacija na C-20 i C-21 je verovatno katalizovana istim enzimom.
Reference
uredi- ↑ Martin, K.O., Oh, S.-W., Lee, H.J. and Monder, C. (1977). „Studies on 21-3H-labeled corticosteroids: evidence for isomerization of the ketol side chain of 11-deoxycorticosterone by a hamster liver enzyme”. Biochemistry 16: 3803-3809. PMID 901753.
- ↑ Monder, C., Martin, K.O. and Bogumil, J. (1980). „Presence of epimerase activity in hamster liver corticosteroid side chain isomerase”. J. Biol. Chem. 255: 7192-7198. PMID 7391077.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.