Kopal-8-ol difosfatna hidrataza
Kopal-8-ol difosfatna hidrataza (EC 4.2.1.133, CcCLS) je enzim sa sistematskim imenom geranilgeranil-difosfat hidrolijaza (formira (13E)-8alfa-hidroksilabda-13-en-15-il difosfat).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kopal-8-ol difosfatna hidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.133 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (13E)-8alfa-hidroksilabda-13-en-15-il difosfat geranilgeranil difosfat + H2O
Za dejstvo ovog enzima je neophodan jon Mg2+.
Reference uredi
- ↑ Falara, V., Pichersky, E. and Kanellis, A.K. (2010). „A copal-8-ol diphosphate synthase from the angiosperm Cistus creticus' subsp. creticus is a putative key enzyme for the formation of pharmacologically active, oxygen-containing labdane-type diterpenes”. Plant Physiol. 154: 301-310. PMID 20595348.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.