Kolumbamin oksidaza
Kolumbamin oksidaza (EC 1.21.3.2, berberinska sintaza) je enzim sa sistematskim imenom kolumbamin:kiseonik oksidoreduktaza (ciklizacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kolumbamin oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.21.3.2 | ||||||||
| CAS broj | 95329-18-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 kolumbamin + O2 2 berberin + 2H2O
Ovaj enzim sadrži gvožđe. Oksidacijom O-metoksifenolne strukture se formira metilindioksi grupa berberina.
Reference uredi
- ↑ Rueffer, M. and Zenk, M.H. (1985). „Berberine synthesis, the methylenedioxy group forming enzyme in berberine synthesis”. Tetrahedron Lett. 26: 201-202.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.