Kobirinat a,c-diamidna sintaza
Kobirinat a,c-diamidna sintaza (EC 6.3.5.11, kobirinska kiselina a,c-diamidna sintetaza, CbiA (gen)) je enzim.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kobirinat a,c-diamidna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.5.11 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 ATP + kobirinat + 2 L-glutamin + 2H2O 2 ADP + 2 fosfat + kobirinat a,c-diamid + 2 L-glutamat (sveukupna reakcija)
- (1a) ATP + kobirinat + L-glutamin + H2O ADP + fosfat + kobirinat c-monamid + L-glutamat
- (1b) ATP + kobirinat c-monamid + L-glutamin + H2O ADP + fosfat + kobirinat a,c-diamid + L-glutamat
Ovaj enzim je prva glutaminska amidotransferaza koja učestvuje u anaerobnoj biosintezi adenozilkobalamina.
Reference
urediLiteratura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.