Koagulacioni faktor XIIa
(Preusmjereno sa stranice Koagulacioni faktor-XIIa)
Koagulacioni faktor XIIa (EC 3.4.21.38, Hagemanov faktor (aktiviran), krvno-koagulacioni faktor XIIf, aktivirani beta krvno-koagulacioni faktor XII, prealbuminski aktivator, Hagemanov faktor beta-fragment, Hagemanov faktor fragment HFf, krvno-koagulacioni faktor XIIabeta, prekalikreinski aktivator, kalikreinogenski aktivator) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Koagulacioni faktor XIIa | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.38 | ||||||||
| CAS broj | 75216-42-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Selectivno razlaganje Arg-Ile veza u faktoru VII čime se formira faktor VIIa, i faktora XI čime se formira faktor XIa
Ovaj enzim takođe aktivira plazminogen i prokalikrein plazme.
Reference uredi
- ↑ Fujikawa, K. and Davie, E.W. (1981). „Human factor XII (Hageman factor)”. Methods Enzymol. 80: 198-211. PMID 6918768.
- ↑ Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. (1984). „Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates”. Biochemistry 23: 644-650. PMID 6370301.
- ↑ Que, B.G. and Davie, E.W. (1986). „Characterization of a cDNA coding for human factor XII (Hageman factor)”. Biochemistry 25: 1525-1528. PMID 3011063.
- ↑ Fujikawa, K. (1988). „Bovine Hageman factor and its fragments”. Methods Enzymol. 163: 54-68. PMID 3237089.
- ↑ Silverberg, M. and Kaplan, A.P. (1988). „Human Hageman factor and its fragments”. Methods Enzymol. 163: 68-80. PMID 3237092.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.