Kinurenin 3-monooksigenaza
Kinurenin 3-monooksigenaza (EC 1.14.13.9, kinureninska 3-hidroksilaza, kinureninska hidroksilaza, L-kinurenin-3-hidroksilaza) je enzim sa sistematskim imenom L-kinurenin,NADPH:kiseonik oksidoreduktaza (3-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kinurenin 3-monooksigenaza | |||||||||
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| Kinurenin 3-monooksigenaza homodimer, Rattus norvegicus | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.14.13.9 | ||||||||
| CAS broj | 9029-61-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- L-kinurenin + NADPH + H+ + O2 3-hidroksi-L-kinurenin + NADP+ + H2O
Ovaj enzim je flavoprotein (FAD).
Reference
uredi- ↑ de Castro, F.T., Price, J.M. and Brown, R.R. (1956). „Reduced triphosphopyridinenucleotide requirement for the enzymatic formation of 3-hydroxykynurenine from L-kynurenine”. J. Am. Chem. Soc. 78: 2904-2905.
- ↑ Okamoto, H. and Hayaishi, O. (1967). „Flavin adenine dinucleotide requirement for kynurenine hydroxylase of rat liver mitochondria”. Biochem. Biophys. Res. Commun. 29: 394-399. PMID 6076241.
- ↑ Saito, Y., Hayaishi, O. and Rothberg, S. (1957). „Studies on oxygenases: enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine”. J. Biol. Chem. 229: 921-934. PMID 13502353.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.