Katepsin V
Katepsin V (EC 3.4.22.43, katepsin L2, katepsin U) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Katepsin V | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.43 | ||||||||
| CAS broj | 223670-00-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Ovaj rekombinantni enzim hidrolizuje proteine (serumski albumin, kolagen) i sintetičke supstrate (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec)
Katepsin V je ljudska lizozomalna cisteinska endopeptidaza iz familije C1 (papainske familije) koja je maksimalno aktivna na pH 5m7 i nestabilna na neutralnom pH.
Reference uredi
- ↑ Brömme, D., Li, Z., Barnes, M. and Mehler, E. (1999). „Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization”. Biochemistry 38: 2377-2385. PMID 10029531.
- ↑ Adachi, W., Kawamoto, S., Ohno, I., Nishida, K., Kinoshita, S., Matsubara, K. and Okubo, K. (1998). „Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium”. Invest. Ophthalmol. Vis. Sci. 39: 1789-1796. PMID 9727401.
- ↑ Santamaría, I., Velasco, G., Cazorla, M., Fueyo, A., Campo, E. and López-Otín, C. (1998). „Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas”. Cancer Res. 58: 1624-1630. PMID 9563472.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.