Katepsin-D
Katepsin-D (EC 3.4.23.5, Cathepsin D) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Katepsin-D | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.5 | ||||||||
| CAS broj | 9025-26-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Specifičnost je slična, mada uža, od pepsina A. Ne dolazi do razlaganja Gln4-His veze u B lancu insulina
Ovaj enzim se javlja intraćelijski u lizozomima.
Reference uredi
- ↑ Barrett, A.J. (1977). „Cathepsin D and other carboxyl proteinases”. u: Barrett, A.J.. Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.. str. 209-248.
- ↑ Takahashi, T. and Tang, J. (1981). „Cathepsin D from porcine and bovine spleen”. Methods Enzymol. 80: 565-581. PMID 7341918.
- ↑ Faust, P.L., Kornfeld, S. and Chirgwin, J.M. (1985). „Cloning and sequence analysis of cDNA for human cathepsin D”. Proc. Natl. Acad. Sci. USA 82: 4910-4914. PMID 3927292.
- ↑ Conner, G.E. (1989). „Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme”. Biochem. J. 263: 601-604. PMID 2512908.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Barrett, A.J. (1977). „Cathepsin D and other carboxyl proteinases”. u: Barrett, A.J.. Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.. str. 209-248.