Karnitin O-oktanoiltransferaza
Karnitin O-oktanoiltransferaza (EC 2.3.1.137, srednjelančana/dugolančana karnitin aciltransferaza, karnitin srednjelančana aciltransferaza, lako rastvorna mitohondrijska karnitinska palmitoiltransferaza) je enzim sa sistematskim imenom oktanoil-KoA:L-karnitin O-oktanoiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Karnitin O-oktanoiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.137 | ||||||||
| CAS broj | 39369-19-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- oktanoil-KoA + L-karnitin KoA + L-oktanoilkarnitin
Ovaj enzim deluje na opseg acil-KoA molekula, sa optimalnom aktivnošću na C6 ili C8 acil grupama, cf. EC 2.3.1.7 (karnitin O-acetiltransferaza) i EC 2.3.1.21 (karnitin O-palmitoiltransferaza).
Reference
uredi- ↑ Farrell, S.O., Fiol, C.J., Reddy, J.K. and Bieber, L.L. (1984). „Properties of purified carnitine acyltransferases of mouse liver peroxisomes”. J. Biol. Chem. 259: 13089-13095. PMID 6436243.
- ↑ Healy, M.J., Kerner, J. and Bieber, L.L. (1988). „Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?”. Biochem. J. 249: 231-237. PMID 3342008.
- ↑ Miyazawa, S., Ozasa, H., Osumi, T. and Hashimoto, T. (1983). „Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver”. J. Biochem. (Tokyo) 94: 529-542. PMID 6630173.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.