3-Dezoksi-8-fosfooktulonat sintaza
(Preusmjereno sa stranice KDOP sintaza)
3-Dezoksi-8-fosfooktulonat sintaza (EC 2.5.1.55, 2-dehidro-3-dezoksi-D-oktonat-8-fosfat D-arabinoza-5-fosfat-lijaza (piruvatna fosforilacija), 2-dehidro-3-dezoksi-fosfooktonat aldolaza, 2-keto-3-dezoksi-8-fosfooktonska sintetaza, 3-dezoksi-D-mano-oktulozonat-8-fosfatna sintaza, 3-dezoksi-D-manooktulozonat-8-fosfat sintetaza, 3-dezoksioktulozonska 8-fosfat sintetaza, KDOP sintaza, fosfo-2-keto-3-dezoksioktonat aldolaza) je enzim sa sistematskim imenom fosfoenolpiruvat:D-arabinoza-5-fosfat C-(1-karboksivinil)transferaza (fosfatna hidroliza, formira 2-karboksi-2-oksoetil).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3-Dezoksi-8-fosfooktulonat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.55 | ||||||||
| CAS broj | 9026-96-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- fosfoenolpiruvat + D-arabinoza 5-fosfat + H 2O 2-dehidro-3-dezoksi-D-oktonat 8-fosfat + fosfat
Reference uredi
- ↑ Levin, D.H. and Racker, E. (1959). „Condensation of arabinose 5-phosphate and phosphorylenol pyruvate by 2-keto-3-deoxy-8-phosphooctonic acid synthetase”. J. Biol. Chem. 234: 2532-25339. PMID 14416200.
- ↑ Krosky, D.J., Alm, R., Berg, M., Carmel, G., Tummino, P.J., Xu, B. and Yang, W. (2002). „Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) synthase is a zinc-metalloenzyme”. Biochim. Biophys. Acta 1594: 297-306. PMID 11904225.
- ↑ Asojo, O., Friedman, J., Adir, N., Belakhov, V., Shoham, Y. and Baasov, T. (2001). „Crystal structures of KDOP synthase in its binary complexes with the substrate phosphoenolpyruvate and with a mechanism-based inhibitor”. Biochemistry 40: 6326-6334. PMID 11371194.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.