Dugolančana 3-oksoacil-KoA reduktaza
Dugolančana 3-oksoacil-KoA reduktaza (EC 1.1.1.330, dugolančana 3-ketoacil-KoA reduktaza, dugolančana beta-ketoacil-KoA reduktaza, KCR (gen), IFA38 (gen)) je enzim sa sistematskim imenom (3R)-3-hidroksiacil-KoA:NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dugolančana 3-oksoacil-KoA reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.330 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- veoma dugačak lanac (3R)-3-hidroksiacil-KoA + NADP+ veoma dugačak lanac 3-oksoacil-KoA + NADPH + H+
Ovaj enzim je druga komponenta elongaze, mikrozomalnog proteinskog kompleksa odgovornog za produžavanje palmitoil-KoA i stearoil-KoA (i njihovih modifikovanih formi) do dugolančanih konenzima A. On je aktivan na supstratima sa lancom dugim od C16 do C34, u zavisnosti od vrste, cf. EC 2.3.1.199, dugolančana 3-oksoacil-KoA sintaza, EC 4.2.1.134, dugolančana (3R)-3-hidroksiacil-[acil-nosilac protein] dehidrataza, i EC 1.3.1.93, dugolančana enoil-KoA reduktaza.
Reference uredi
- ↑ Beaudoin, F., Gable, K., Sayanova, O., Dunn, T. and Napier, J.A. (2002). „A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal β-keto-reductase”. J. Biol. Chem. 277: 11481-11488. PMID 11792704.
- ↑ Han, G., Gable, K., Kohlwein, S.D., Beaudoin, F., Napier, J.A. and Dunn, T.M. (2002). „The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase”. J. Biol. Chem. 277: 35440-35449. PMID 12087109.
- ↑ Beaudoin, F., Wu, X., Li, F., Haslam, R.P., Markham, J.E., Zheng, H., Napier, J.A. and Kunst, L. (2009). „Functional characterization of the Arabidopsis β-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase”. Plant Physiol. 150: 1174-1191. PMID 19439572.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.