Japsin 1
Japsin 1 (EC 3.4.23.41, kvašćana aspartinska proteaza 3, Yap3 genski produkt (Saccharomyces cerevisiae)) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Japsin 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.41 | ||||||||
| CAS broj | 205132-58-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Hidroliza raznih prekursornih proteina sa Arg ili Lys u P1, dok su Arg i Lys često u P2. P3 aminokiselina je obično nepolarna
Ovaj enzim pripada peptidaznoj familiji A1 pepsina.
Reference uredi
- ↑ Cawley, N.X., Chen, H.C., Beinfeld, M.C. and Loh, Y.P. (1996). „Specificity and kinetic studies on the cleavage of various prohormone mono- and paired-basic residue sites by yeast aspartic protease 3”. J. Biol. Chem. 271: 4168-4176. PMID 8626758.
- ↑ Fuller, R.S. (1998). „Yapsin 2”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 908-909.
- ↑ Olsen, V., Guruprasad, K., Cawley, N.X., Chen, H.C., Blundell, T.L. and Loh, Y.P. (1998). „Cleavage efficiency of the novel aspartic protease yapsin 1 (Yap3p) enhanced for substrates with arginine residues flanking the P1 site: correlation with electronegative active-site pockets predicted by molecular modeling”. Biochemistry 37: 2768-2777. PMID 9485427.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Fuller, R.S. (1998). „Yapsin 2”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 908-909.