Izopenicilin-N epimeraza
Izopenicilin-N epimeraza (EC 5.1.1.17, Isopenicillin-N epimerase) je enzim sa sistematskim imenom penicilin-N 5-amino-5-karboksipentanoil-epimeraza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Izopenicilin-N epimeraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.1.1.17 | ||||||||
| CAS broj | 88201-43-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- izopenicilin N penicilin N
Ovaj enzim sadrži piridoksal fosfat.
Reference uredi
- ↑ Usui, S. and Yu, C.-A. (1989). „Purification and properties of isopenicillin-N epimerase from Streptomyces clavuligerus”. Biochim. Biophys. Acta 999: 78-85. PMID 2804141.
- ↑ Laiz, L., Liras, P., Castro, J.M. and Martín, J.F. (1990). „Purification and characterization of the isopenicillin-N epimerase from Nocardia lactamdurans”. J. Gen. Microbiol. 136: 663-671.
- ↑ Cantwell, C., Beckmann, R., Whiteman, P., Queener, S.W. and Abraham, E.P. (1992). „Isolation of deacetoxycephalosporin-c from fermentation broths of Penicillium chrysogenum transformants - construction of a new fungal biosynthetic-pathway”. Proc. R. Soc. Lond. B Biol. Sci. 248: 283-289. PMID 1354366.
- ↑ Yeh, W.K., Ghag, S.K. and Queener, S.W. (1992). „Enzymes for epimerization of isopenicillin N, ring expansion of penicillin N, and 3′-hydroxylation of deacetoxycephalosporin C. Function, evolution, refolding, and enzyme engineering”. Ann. N.Y. Acad. Sci. 672: 396-408.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.