Izohorizmatna sintaza
Izohorizmatna sintaza (EC 5.4.4.2, MenF) je enzim sa sistematskim imenom izohorizmat hidroksimutaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Izohorizmatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Izohorizmatna sintaza EntC, monomer, E.Coli | |||||||||
| Identifikatori | |||||||||
| EC broj | 5.4.4.2 | ||||||||
| CAS broj | 37318-53-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- horizmat izohorizmat
Za dejstvo ovog enzima je neophodan Mg2+.
Reference uredi
- ↑ Young, I.G. and Gibson, F. (1969). „Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli”. Biochim. Biophys. Acta 177: 401-411. PMID 4306838.
- ↑ van Tegelen, L.J., Moreno, P.R., Croes, A.F., Verpoorte, R. and Wullems, G.J. (1999). „Purification and cDNA cloning of isochorismate synthase from elicited cell cultures of Catharanthus roseus”. Plant Physiol. 119: 705-712. PMID 9952467.
- ↑ Dahm, C., Müller, R., Schulte, G., Schmidt, K. and Leistner, E. (1998). „The role of isochorismate hydroxymutase genes entC and menF in enterobactin and menaquinone biosynthesis in Escherichia coli”. Biochim. Biophys. Acta 1425: 377-386. PMID 9795253.
- ↑ Daruwala, R., Kwon, O., Meganathan, R. and Hudspeth, M.E. (1996). „A new isochorismate synthase specifically involved in menaquinone (vitamin K2) biosynthesis encoded by the menF gene”. FEMS Microbiol. Lett. 140: 159-163. PMID 8764478.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.