Izohorizmatna lijaza
Izohorizmatna lijaza (EC 4.2.99.21, salicilat biosintezni protein pchB, piohelinski biosintetički protein PchB, izohorizmat piruvatna lijaza) je enzim sa sistematskim imenom izohorizmat piruvat-lijaza (formira salicilat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Izohorizmatna lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.99.21 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ovaj enzim učestvuje u formiranju salicilata iz horizmata.
Reference uredi
- ↑ Serino, L., Reimmann, C., Baur, H., Beyeler, M., Visca, P. and Haas, D. (1995). „Structural genes for salicylate biosynthesis from chorismate in Pseudomonas aeruginosa”. Mol. Gen. Genet. 249: 217-228. PMID 7500944.
- ↑ Kerbarh, O., Ciulli, A., Howard, N.I. and Abell, C. (2005). „Salicylate biosynthesis: overexpression, purification, and characterization of Irp9, a bifunctional salicylate synthase from Yersinia enterocolitica”. J. Bacteriol. 187: 5061-5066. PMID 16030197.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.