Izoflavon 3'-hidroksilaza
Izoflavon 3'-hidroksilaza (EC 1.14.13.52, izoflavonska 3'-monooksigenaza) je enzim sa sistematskim imenom formononetin,NADPH:kiseonik oksidoreduktaza (3'-hidroksilacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Izoflavon 3'-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.52 | ||||||||
| CAS broj | 110183-50-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- formononetin + NADPH + H+ + O2 kalikozin + NADP+ +H2O
Ovaj enzim je hem-tiolatni protein (P-450). On takođe deluje na biohanin A i druge izoflavone sa 4'-metoksi grupom. On učestvuje u biosintezi pterokarpinskog fitoaleksina.
Reference uredi
- ↑ Hinderer, W., Flentje, U. and Barz, W. (1987). „Microsomal isoflavone 2′-hydroxylases and 3′-hydroxylases from chickpea (Cicer arietinum L) cell-suspensions induced for pterocarpan phytoalexin formation”. FEBS Lett. 214: 101-106.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.