Inozitol-1,3,4-trisfosfat 5/6-kinaza
Inozitol-1,3,4-trisfosfat 5/6-kinaza (EC 2.7.1.159, Ins(1,3,4)P3 5/6-kinaza, inozitol trisfosfatna 5/6-kinaza) je enzim sa sistematskim imenom ATP:1D-mio-inozitol 1,3,4-trisfosfat 5-fosfotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Inozitol-1,3,4-trisfosfat 5/6-kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.1.159 | ||||||||
| CAS broj | 288307-53-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) ATP + 1D-mio-inozitol 1,3,4-trisfosfat ADP + 1D-mio-inozitol 1,3,4,5-tetrakisfosfat
- (2) ATP + 1D-mio-inozitol 1,3,4-trisfosfat ADP + 1D-mio-inozitol 1,3,4,6-tetrakisfosfat
Kod ljudi, ovaj enzim, zajedno sa EC 2.7.1.127 (inozitol-trisfosfat 3-kinazom), EC 2.7.1.140 (inozitol-tetrakisfosfat 5-kinazom) i EC 2.7.1.158 (inozitol pentakisfosfat 2-kinazom) učestvuje u produkciji inozitol heksakisfosfata (InsP6).
Reference
uredi- ↑ Wilson, M.P. and Majerus, P.W. (1996). „Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme”. J. Biol. Chem. 271: 11904-11910. PMID 8662638.
- ↑ Verbsky, J.W., Chang, S.C., Wilson, M.P., Mochizuki, Y. and Majerus, P.W. (2005). „The pathway for the production of inositol hexakisphosphate in human cells”. J. Biol. Chem. 280: 1911-1920. PMID 15531582.
- ↑ Miller, G.J., Wilson, M.P., Majerus, P.W. and Hurley, J.H. (2005). „Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase”. Mol. Cell. 18: 201-212. PMID 15837423.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.