IRNK (guanin-N7-)-metiltransferaza
iRNK (guanin-N7-)-metiltransferaza (EC 2.1.1.56, informaciona ribonukleatni guanin 7-metiltransferaza, guanin-7-metiltransferaza, informaciona RNK guanin 7-metiltransferaza, S-adenozil-L-metionin:iRNK (guanin-7-N)-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:iRNK (guanin-N7)-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| iRNK (guanin-N7-)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.56 | ||||||||
| CAS broj | 56941-25-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- S-adenozil-L-metionin + G5'ppp5'R-iRNK S-adenozil-L-homocistein + m7G5'ppp5'R-iRNK
Nukleozid pored terminalnog guanozina može da bude bilo guanozin ili adenozin.
Reference
uredi- ↑ Ensinger, M.J., Martin, S.A., Paoletti, E. and Moss, B. (1975). „Modification of the 5′-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus”. Proc. Natl. Acad. Sci. USA 72: 2525-2529. PMID 1058472.
- ↑ Groner, Y., Gilbao, E. and Aviv, H. (1978). „Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates”. Biochemistry 17: 977-982. PMID 629955.
- ↑ Martin, S.A. and Moss, B. (1975). „Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7)methyltransferase from vaccinia virions”. J. Biol. Chem. 250: 9330-9335. PMID 1194287.
- ↑ Martin, S.A., Paoletti, E. and Moss, B. (1975). „Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions”. J. Biol. Chem. 250: 9322-9329. PMID 1194286.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.