Inozitol-pentakisfosfat 2-kinaza
(Preusmjereno sa stranice IP5 2-kinaza)
Inozitol-pentakisfosfat 2-kinaza (EC 2.7.1.158, IP5 2-kinaza, Gsl1p, Ipk1p, inozitol polifosfatna kinaza, inozitol 1,3,4,5,6-pentakisfosfatna 2-kinaza, Ins(1,3,4,5,6)P5 2-kinaza) je enzim sa sistematskim imenom ATP:1D-mio-inozitol 1,3,4,5,6-pentakisfosfat 2-fosfotransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Inozitol-pentakisfosfat 2-kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.1.158 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ovaj enzim takođe može da koristi Ins(1,4,5,6)P4 i Ins(1,4,5)P3 kao supstrat.
Reference uredi
- ↑ York, J.D., Odom, A.R., Murphy, R., Ives, E.B. and Wente, S.R. (1999). „A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export”. Science 285: 96-100. PMID 10390371.
- ↑ Phillippy, B.Q., Ullah, A.H. and Ehrlich, K.C. (1994). „Purification and some properties of inositol 1,3,4,5,6-Pentakisphosphate 2-kinase from immature soybean seeds”. J. Biol. Chem. 269: 28393-28399. PMID 7961779.
- ↑ Phillippy, B.Q., Ullah, A.H. and Ehrlich, K.C. (1997). „Additions and corrections to Purification and some properties of inositol 1,3,4,5,6-pentakisphosphate 2-kinase from immature soybean seeds”. J. Biol. Chem. 270: 7782-7782.
- ↑ Ongusaha, P.P., Hughes, P.J., Davey, J. and Michell, R.H. (1998). „Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation”. Biochem. J. 335: 671-679. PMID 9794810.
- ↑ Miller, A.L., Suntharalingam, M., Johnson, S.L., Audhya, A., Emr, S.D. and Wente, S.R. (2004). „Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway”. J. Biol. Chem. 279: 51022-51032. PMID 15459192.
- ↑ Stevenson-Paulik, J., Odom, A.R. and York, J.D. (2002). „Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases”. J. Biol. Chem. 277: 42711-42718. PMID 12226109.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.