Inozitol-polifosfat multikinaza
(Preusmjereno sa stranice IP3/IP4 dual-specificity 6-/3-kinase)
Inozitol-polifosfat multikinaza (EC 2.7.1.151, IpK2, IP3/IP4 6-/3-kinaza, IP3/IP4 dualno-specifična 6-/3-kinaza, IpmK, ArgRIII, AtIpk2alfa, AtIpk2beta, inozitol polifosfatna 6-/3-/5-kinaza) je enzim sa sistematskim imenom ATP:1D-mio-inozitol-1,4,5-trisfosfat 6-fosfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Inozitol-polifosfat multikinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.1.151 | ||||||||
| CAS broj | 9077-69-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 ATP + 1D-mio-inozitol 1,4,5-trisfosfat 2 ADP + 1D-mio-inozitol 1,3,4,5,6-pentakisfosfat (sveukupna reakcija)
- (1a) ATP + 1D-mio-inozitol 1,4,5-trisfosfat ADP + 1D-mio-inozitol 1,4,5,6-tetrakisfosfat
- (1b) ATP + 1D-mio-inozitol 1,4,5,6-tetrakisfosfat ADP + 1D-mio-inozitol 1,3,4,5,6-pentakisfosfat
Ovaj enzim takođe fosforiliše Ins(1,4,5)P3 do Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 do Ins(1,3,4,5,6)P5, i Ins(1,3,4,5,6)P4 do Ins(PP)P4, nepoznatog izomera.
Reference
uredi- ↑ Saiardi, A., Erdjument-Bromage, H., Snowman, A.M., Tempst, P. and Snyder, S.H. (1999). „Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases”. Curr. Biol. 9: 1323-1326. PMID 10574768.
- ↑ Odom, A.R., Stahlberg, A., Wente, S.R. and York, J.D. (2000). „A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control”. Science 287: 2026-2029. PMID 10720331.
- ↑ Stevenson-Paulik, J., Odom, A.R. and York, J.D. (2002). „Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases”. J. Biol. Chem. 277: 42711-42718. PMID 12226109.
- ↑ Verbsky, J.W., Chang, S.C., Wilson, M.P., Mochizuki, Y. and Majerus, P.W. (2005). „The pathway for the production of inositol hexakisphosphate in human cells”. J. Biol. Chem. 280: 1911-1920. PMID 15531582.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.