IMP dehidrogenaza
(Preusmjereno sa stranice IMP oksidoreduktaza)
IMP dehidrogenaza (EC 1.1.1.205, inozin-5'-fosfat dehidrogenaza, inozinska kiselina dehidrogenaza, inozinat dehidrogenaza, inozin 5'-monofosfat dehidrogenaza, inozin monofosfat dehidrogenaza, IMP oksidoreduktaza, inozin monofosfat oksidoreduktaza) je enzim sa sistematskim imenom IMP:NAD+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| IMP dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Struktura IMP dehidrogenaze | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.205 | ||||||||
| CAS broj | 9028-93-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- IMP + NAD+ +H2O XMP + NADH + H+
Ovaj enzim deluje na hidroksi grupu hidratisanog derivata supstrata.
Reference
uredi- ↑ Magasanik, B., Moyed, H.S. and Gehring, L.B. (1957). „Enzymes essential for the biosynthesis of nucleic acid guanine; inosine 5′-phosphate dehydrogenase of Aerobacter aerogenes”. J. Biol. Chem. 226: 339-350. PMID 13428767.
- ↑ Turner, J.F. and King, J.E. (1961). „Inosine 5-phosphate dehydrogenase of pea seeds”. Biochem. J. 79: 147-147. PMID 13778733.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.