Hondroitin 4-sulfotransferaza
Hondroitin 4-sulfotransferaza (EC 2.8.2.5, hondroitinska sulfotransferaza) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:hondroitin 4'-sulfotransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hondroitin 4-sulfotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.2.5 | ||||||||
| CAS broj | 83589-04-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 3'-fosfoadenilil sulfat + hondroitin adenozin 3',5'-bisfosfat + hondroitin 4'-sulfat
Sulfatacija se odvija u 4-poziciji N-acetil-galaktozaminskih ostataka hondroitina.
Reference
uredi- ↑ Habuchi, O. and Miyashita, N. (1982). „Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage”. Biochim. Biophys. Acta 717: 414-421. PMID 6957247.
- ↑ Nakanishi, Y., Otsu, K. and Suzuki, S. (1983). „Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine”. FEBS Lett. 151: 15-18. PMID 6130977.
- ↑ Nakanishi, Y., Shimizu, M., Otsu, K., Kato, S., Tsuji, M. and Suzuki, S. (1981). „A terminal 6-sulfotransferase catalyzing a synthesis of N-acetylgalactosamine 4,6-bissulfate residue at the nonreducing terminal position of chondroitin sulfate”. J. Biol. Chem. 256: 5443-5449. PMID 6787041.
- ↑ Suzuki, S. and Strominger, J.L. (1960). „Enzymatic sulfation of mucopolysaccharides in hen oviduct. I. Transfer of sulfate from 3′-phosphoadenosine 5′-phosphosulfate to mucopolysaccharides”. J. Biol. Chem. 235: 257-266. PMID 13835879.
- ↑ Suzuki, S. and Strominger, J.L. (1960). „Enzymatic sulfation of mucopolysaccharides in hen oviduct. II. Mechanism of the reaction studied with oligosaccharides and monosaccharides as acceptors”. J. Biol. Chem. 235: 267-273. PMID 13835880.
- ↑ Suzuki, S. and Strominger, J.L. (1960). „Enzymatic sulfation of mucopolysaccharides in hen oviduct. III. Mechanism of sulfation of chondroitin and chondroitin sulfate A”. J. Biol. Chem. 235: 274-276. PMID 13835881.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.