Holo-ACP sintaza
Holo-ACP sintaza (EC 2.7.7.61, 2'-(5-fosforibozil)-3'-defosfo-KoA transferaza, 2'-(5-trifosforibozil)-3'-defosfo-KoA:apo-citrat lijaza, CitX, 2'-(5-trifosforibozil)-3'-defosfo-KoA:apo-citrat lijaza adenililtransferaza, 2'-(5-trifosforibozil)-3'-defosfo-KoA:apo-citrat lijaza 2'-(5-trifosforibozil)-3'-defosfo-KoA transferaza, 2'-(5-trifosforibozil)-3'-defosfo-KoA:apo-citrat-lijaza adenililtransferaza, holo-citrat lijaza sintaza) je enzim sa sistematskim imenom 2'-(5-trifosforibozil)-3'-defosfo-KoA:apo-citrat-lijaza 2'-(5-fosforibozil)-3'-defosfo-KoA-transferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Holo-ACP sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.7.61 | ||||||||
| CAS broj | 312492-44-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2'-(5-trifosforibozil)-3'-defosfo-KoA + citrat lijaza apo-[acil-nosilac protein] citrat lijaza holo-[acil-nosilac protein] + difosfat
Gama-podjedinica EC 4.1.3.6, citrat (pro-3S) lijaza, služi kao acil-noseći protein (ACP).
Reference
uredi- ↑ Schneider, K., Dimroth, P. and Bott, M. (2000). „Biosynthesis of the prosthetic group of citrate lyase”. Biochemistry 39: 9438-9450. PMID 10924139.
- ↑ Schneider, K., Dimroth, P. and Bott, M. (2000). „Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group”. FEBS Lett. 483: 165-168. PMID 11042274.
- ↑ Schneider, K., Kästner, C.N., Meyer, M., Wessel, M., Dimroth, P. and Bott, M. (2002). „Identification of a gene cluster in Klebsiella pneumoniae which includes citX, a gene required for biosynthesis of the citrate lyase prosthetic group”. J. Bacteriol. 184: 2439-2446. PMID 11948157.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.