Holesterol 24-hidroksilaza
Holesterol 24-hidroksilaza (EC 1.14.13.98, holesterol 24-monooksigenaza, CYP46, CYP46A1, holesterolna 24S-hidroksilaza, citohromna P450 46A1) je enzim sa sistematskim imenom holesterol,NADPH:kiseonik oksidoreduktaza (24-hidroksilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Holesterol 24-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.98 | ||||||||
| CAS broj | 213327-78-7&title= 50812-30-1, 213327-78-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- holesterol + NADPH + H+ + O2 (24S)-24-hidroksiholesterol + NADP+ + H2O
Ovaj enzim je hem-tiolatni protein (P-450). On takođe može da formira 25-hidroksiholesterol.
Reference
uredi- ↑ Lund, E.G., Guileyardo, J.M. and Russell, D.W. (1999). „cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain”. Proc. Natl. Acad. Sci. USA 96: 7238-7243. PMID 10377398.
- ↑ Mast, N., Norcross, R., Andersson, U., Shou, M., Nakayama, K., Bjorkhem, I. and Pikuleva, I.A. (2003). „Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain”. Biochemistry 42: 14284-14292. PMID 14640697.
- ↑ Lund, E.G., Xie, C., Kotti, T., Turley, S.D., Dietschy, J.M. and Russell, D.W. (2003). „Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover”. J. Biol. Chem. 278: 22980-22988. PMID 12686551.
- ↑ Bogdanovic, N., Bretillon, L., Lund, E.G., Diczfalusy, U., Lannfelt, L., Winblad, B., Russell, D.W. and Björkhem, I. (2001). „On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells.”. Neurosci. Lett. 314: 45-48. PMID 11698143.
- ↑ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137-174. PMID 12543708.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.