Hiosciamin (6S)-dioksigenaza
Hiosciamin (6S)-dioksigenaza (EC 1.14.11.11, hiosciaminska 6beta-hidroksilaza, hiosciaminska 6beta-dioksigenaza, hiosciaminska 6-hidroksilaza) je enzim sa sistematskim imenom L-hiosciamin,2-oksoglutarat:kiseonik oksidoreduktaza ((6S)-hidroksilacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hiosciamin (6S)-dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.11.11 | ||||||||
| CAS broj | 103865-33-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-hiosciamin + 2-oksoglutarat + O2 (6S)-hidroksihiosciamin + sukcinat + CO2
Za rad ovog enzima se neophodni Fe2+ i askorbat.
Reference uredi
- ↑ Hashimoto, T. and Yamada, Y. (1986). „Hyoscyamine 6β-hydroxylase, a 2-oxoglutarate-dependent dioxygenase, in alkaloid-producing root cultures”. Plant Physiol. 81: 619-625. PMID 16664866.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.