Hinat dehidrogenaza
Hinat dehidrogenaza (EC 1.1.1.24, hinatna dehidrogenaza, hinatna dehidrogenaza, hinat:NAD oksidoreduktaza, hinat 5-dehidrogenaza, hinat:NAD+ 5-oksidoreduktaza) je enzim sa sistematskim imenom L-hinat:NAD+ 3-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hinat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.24 | ||||||||
| CAS broj | 9028-28-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-hinat + NAD+ 3-dehidrohinat + NADH + H+
Ovaj enzim je specifičan za hinat kao supstrat; fenilpiruvat, fenilalanin, cinamat i šikimat ne deluju kao supstrati. NAD+ ne može da bude zamenjen sa NADP+.
Reference uredi
- ↑ Gamborg, O.L. (1966). „Aromatic metabolism in plants. III. Quinate dehydrogenase from mung bean cell suspension cultures”. Biochim. Biophys. Acta 128: 483-491.
- ↑ Mitsuhashi, S. and Davis, B.D. (1954). „Aromatic biosynthesis. XIII. Conversion of quinic acid to 5-dehydroquinic acid by quinic dehydrogenase”. Biochim. Biophys. Acta 15: 268-280. PMID 13208693.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.