Hinat O-hidroksicinamoiltransferaza
Hinat O-hidroksicinamoiltransferaza (EC 2.3.1.99, hidroksicinamoil koenzim A-hinat transferaza) je enzim sa sistematskim imenom feruloil-KoA:hinat O-(hidroksicinamoil)transferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Hinat O-hidroksicinamoiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.99 | ||||||||
| CAS broj | 60321-02-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- feruloil-KoA + hinat KoA + O-feruloilhinat
Kofeoil-KoA i 4-kumaroil-KoA takođe mogu da deluju kao donori, mada sporije. Ovaj enzim učestvuje u biosintezi hlorogene kiseline u slatkom krompiru, i sa enzimom EC 2.3.1.98, hlorogenat---glukarat O-hidroksicinamoiltransferaza, u formiranju kafeoil-KoA u paradajzu.
Reference
uredi- ↑ Strack, D., Gross, W., Wray, V. and Grotjahn, L. (1987). „Enzymatic-synthesis of caffeoylglucaric acid from chlorogenic acid and glucaric acid by a protein preparation from tomato cotyledons”. Plant Physiol. 83: 475-478. PMID 16665274.
- ↑ Strack, D., Keller, H. and Weissenböck, G. (1987). „Enzymatic-synthesis of hydroxycinnamic acid-esters of sugar acids and hydroaromatic acids by protein preparations from rye (Secale cereale) primary leaves”. J. Plant Physiol. 131: 61-73.
- ↑ Villegas, R.J.A. and Kojima, M. (1986). „Purification and characterization of hydroxycinnamoyl D-glucose. Quinate hydroxycinnamoyl transferase in the root of sweet potato, Ipomoea batatas Lam”. J. Biol. Chem. 261: 8729-8733. PMID 3722170.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.