Hidroperoksidna dehidrataza
Hidroperoksidna dehidrataza (EC 4.2.1.92, hidroperoksidna izomeraza, linoleat hidroperoksidna izomeraza, linoleinsko kiselinska hidroperoksidna izomeraza, HPI, (9Z,11E,14Z)-(13S)-hidroperoksioktadeka-9,11,14-trienoat 12,13-hidrolijaza, (9Z,11E,14Z)-(13S)-hidroperoksioktadeka-9,11,14-trienoat 12,13-hidrolijaza (formira (9Z)-(13S)-12,13-epoksioktadeka-9,11-dienoat), alen oksidna sintaza, AOS) je enzim sa sistematskim imenom (9Z,11E,15Z)-(13S)-hidroperoksioktadeka-9,11,15-trienoat 12,13-hidrolijaza (formira (9Z,15Z)-(13S)-12,13-epoksioktadeka-9,11,15-trienoat).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hidroperoksidna dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.92 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (9Z,11E,15Z)-(13S)-hidroperoksioktadeka-9,11,15-trienoat (9Z,15Z)-(13S)-12,13-epoksioktadeka-9,11,15-trienoat + H2O
Ovaj enzim deluje brojne nezasićene masno-kiselinske hidroperokside.
Reference uredi
- ↑ Esselman, W.J. and Clagett, C.O. (1974). „Products of linoleic hydroperoxide-decomposing enzyme of alfalfa seed”. J. Lipid Res. 15: 173-178. PMID 4208994.
- ↑ Hamberg, M. (1987). „Mechanism of corn hydroperoxide isomerase - detection of 12,13(S)-oxido-9(Z),11-octadecadienoic acid”. Biochim. Biophys. Acta 920: 76-84.
- ↑ Hamberg, M. (1988). „Biosynthesis of 12-oxo-10,15(Z)-phytodienoic acid: identification of an allene oxide cyclase”. Biochem. Biophys. Res. Commun. 156: 543-550. PMID 3178850.
- ↑ Laudert, D., Pfannschmidt, U., Lottspeich, F., Holländer-Czytko, H. and Weiler, E.W. (1996). „Cloning, molecular and functional characterization of Arabidopsis thaliana allene oxide synthase (CYP 74), the first enzyme of the octadecanoid pathway to jasmonates”. Plant Mol. Biol. 31: 323-335. PMID 8756596.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.