Hidroksimandelonitrilna lijaza
Hidroksimandelonitrilna lijaza (EC 4.1.2.11, hidroksinitrilna lijaza, oksinitrilaza, Sorghum hidroksinitrilna lijaza, (S)-4-hidroksimandelonitril hidroksibenzaldehid-lijaza) je enzim sa sistematskim imenom (S)-4-hidroksimandelonitril 4-hidroksibenzaldehid-lijaza (formira cijanid).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hidroksimandelonitrilna lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.2.11 | ||||||||
| CAS broj | 9075-38-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (S)-4-hidroksimandelonitril cijanid + 4-hidroksibenzaldehid
Ovaj enzim ne deluje na alifatične hidroksinitrile.
Reference uredi
- ↑ Bové, C. and Conn, E.E. (1961). „Metabolism of aromatic compounds in higher plants. II. Purification and properties of the oxynitrilase of Sorghum vulgare”. J. Biol. Chem. 236: 207-210. PMID 16495254.
- ↑ Seely, M.K., Criddle, R.S. and Conn, E.E. (1966). „The metabolism of aromatic compounds in higher plants. 8. On the requirement of hydroxynitrile lyase for flavin”. J. Biol. Chem. 241: 4457-4462. PMID 5922969.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.