6-Hidroksinikotinat 3-monooksigenaza
(Preusmjereno sa stranice HNA-3-monooxygenase)
6-hidroksinikotinat 3-monooksigenaza (EC 1.14.13.114, NicC, 6HNA monooksigenaza, HNA-3-monooksigenaza) je enzim sa sistematskim imenom 6-hidroksinikotinat,NADH:kiseonik oksidoreduktaza (3-hidroksilacija, dekarboksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 6-hidroksinikotinat 3-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.114 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 6-hidroksinikotinat + NADH + H+ + O2 2,5-dihidroksipiridin + NAD+ + H2O + CO2
Ovaj enzim je flavoprotein (FAD). Reakcija obuhvata aerobni katabolizam nikotinske kiseline.
Reference uredi
- ↑ Nakano, H., Wieser, M., Hurh, B., Kawai, T., Yoshida, T., Yamane, T. and Nagasawa, T. (1999). „Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5”. Eur. J. Biochem. 260: 120-126. PMID 10091591.
- ↑ Jimenez, J.I., Canales, A., Jimenez-Barbero, J., Ginalski, K., Rychlewski, L., Garcia, J.L. and Diaz, E. (2008). „Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440”. Proc. Natl. Acad. Sci. USA 105: 11329-11334. PMID 18678916.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.