Hidroksimetilglutaril-KoA reduktaza (NADPH)
Hidroksimetilglutaril-KoA reduktaza (NADPH) (EC 1.1.1.34, hidroksimetilglutaril koenzim A reduktaza (redukovani nikotinamid adenin dinukleotid fosfat), 3-hidroksi-3-metilglutaril-KoA reduktaza, beta-hidroksi-beta-metilglutaril koenzim A reduktaza, hidroksimetilglutaril KoA reduktaza (NADPH), S-3-hidroksi-3-metilglutaril-KoA reduktaza, NADPH-hidroksimetilglutaril-KoA reduktaza, HMGKoA reduktaza-mevalonat:NADP-oksidoreduktaza (acetilacija KoA), 3-hidroksi-3-metilglutaril KoA reduktaza (NADPH), hidroksimetilglutaril-KoA reduktaza (NADPH2)) je enzim sa sistematskim imenom (R)-mevalonat:NADP+ oksidoreduktaza (acetilacija KoA).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hidroksimetilglutaril-KoA reduktaza (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| HMG-KoA reduktaza (NADPH) tetramer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.34 | ||||||||
| CAS broj | 9028-35-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (R)-mevalonat + KoA + 2 NADP+ (S)-3-hidroksi-3-metilglutaril-KoA + 2 NADPH + 2 H+
Ovaj enzim inaktivira enzim EC 2.7.11.31, hidroksimetilglutaril-KoA reduktaza (NADPH) kinaza, i reaktivira EC 3.1.3.47, hidroksimetilglutaril-KoA reduktaza (NADPH) fosfataza.
Reference
uredi- ↑ Bucher, N.L.R., Overath, P. and Lynen, F. (1960). „β-Hydroxy-β-methylglutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver”. Biochim. Biophys. Acta 40: 491-501.
- ↑ Durr, I.F. and Rudney, H. (1960). „The reduction of β-hydroxy-β-methylglutaryl coenzyme A to mevalonic acid”. J. Biol. Chem. 235: 2572-2578. PMID 13818862.
- ↑ Kawachi, T. and Rudney, H. (1970). „Solubilization and purification of β-hydroxy-β-methylglutaryl coenzyme A reductase from rat liver”. Biochemistry 9: 1700-1700. PMID 4985697.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.