Hidroksimetilbilan sintaza
(Preusmjereno sa stranice HMB-sintaza)
Hidroksimetilbilan sintaza (EC 2.5.1.61, HMB-sintaza, porphobilinogen deaminaza, pre-uroporfirinogen sintaza, uroporfirinogen I sintaza, uroporfirinogen I sintetaza, uroporfirinogen sintaza, uroporfirinogen sintetaza, porfobilinogen amonijak-lijaza (polimerizacija), (4-(2-karboksietil)-3-(karboksimetil)pirol-2-il)metiltransferaza (hidrolizacija)) je enzim sa sistematskim imenom porfobilinogen:(4-(2-karboksietil)-3-(karboksimetil)pirrol-2-il)metiltransferaza (hidroliza).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hidroksimetilbilan sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Porphobilinogen deaminaza monomer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.5.1.61 | ||||||||
| CAS broj | 9074-91-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4 porfobilinogen +H2O hidroksimetilbilan + 4 NH3
Ovaj enzim deluje putem postepene adicije pirolilmetilnih grupa.
Reference
uredi- ↑ Battersby, A.R., Fookes, C.J.R., Matcham, G.W.J. and McDonald, E. (1980). „Biosynthesis of the pigments of life: formation of the macrocycle”. Nature 285: 17-21. PMID 6769048.
- ↑ Frydman, R.B. and Feinstein, G. (1974). „Studies on porphobilinogen deaminase and uroporphyrinogen 3 cosynthase from human erythrocytes”. Biochim. Biophys. Acta 350: 358-373. PMID 4847568.
- ↑ Levin, E.Y. and Coleman, D.L. (1967). „The enzymatic conversion of porphobilinogen to uroporphyrinogen catalyzed by extracts of hematopoietic mouse spleen”. J. Biol. Chem. 242: 4247-4253. PMID 6061709.
- ↑ Warren, M.J. and Jordan, P.M. (1988). „Investigation into the nature of substrate binding to the dipyrromethane cofactor of Escherichia coli porphobilinogen deaminase”. Biochemistry 27: 9020-9030. PMID 3069132.
- ↑ Miller, A.D., Hart, G.J., Packman, L.C. and Battersby, A.R. (1988). „Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound to the protein through the sulphur atom of cysteine-242”. Biochem. J. 254: 915-918. PMID 3196304.
- ↑ Battersby, A.R. (2000). „Tetrapyrroles: the pigments of life”. Nat. Prod. Rep. 17: 507-526. PMID 11152419.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.