Homoakonitatna hidrataza
(Preusmjereno sa stranice HACN)
Homoakonitatna hidrataza (EC 4.2.1.36, homoakonitaza, cis-homoakonitaza, HACN, Lys4, LysF, 2-hidroksibutan-1,2,4-trikarboksilat hidrolijaza) je enzim sa sistematskim imenom (1R,2S)-1-hidroksibutan-1,2,4-trikarboksilat hidrolijaza (formira (Z)-but-1-en-1,2,4-trikarboksilat).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Homoakonitatna hidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Homoakonitatna hidrataza homodimer, Methanocaldococcus jannaschii | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.2.1.36 | ||||||||
| CAS broj | 9030-68-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (1R,2S)-1-hidroksibutan-1,2,4-trikarboksilat (Z)-but-1-en-1,2,4-trikarboksilat + H2O
Za dejstvo ovog enzima je neophodan [4Fe-4S] klaster.
Reference uredi
- ↑ Strassman, M. and Ceci, L.N. (1966). „Enzymatic formation of cis-homoaconitic acid, an intermediate in lysine biosynthesis in yeast”. J. Biol. Chem. 241: 5401-5407. PMID 5954805.
- ↑ Jia, Y., Tomita, T., Yamauchi, K., Nishiyama, M. and Palmer, D.R. (2006). „Kinetics and product analysis of the reaction catalysed by recombinant homoaconitase from Thermus thermophilus”. Biochem. J. 396: 479-485. PMID 16524361.
- ↑ Zabriskie, T.M. and Jackson, M.D. (2000). „Lysine biosynthesis and metabolism in fungi”. Nat. Prod. Rep. 17: 85-97. PMID 10714900.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.