Glutaminil-tRNK sintaza (glutamin-hidrolizujuća)
Glutaminil-tRNK sintaza (glutamin-hidrolizujuća) (EC 6.3.5.7, Glu-AdT, Glu-tRNKGln amidotransferaza, glutamil-tRNKGln amidotransferaza, Glu-tRNKGln:L-glutamin amido-ligaza (formira ADP)) je enzim sa sistematskim imenom glutamil-tRNKGln:L-glutamin amido-ligaza (formira ADP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glutaminil-tRNK sintaza (glutamin-hidrolizujuća) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.5.7 | ||||||||
| CAS broj | 52232-48-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
U sistemima kojima nedostaje glutamin—tRNK ligaza (EC 6.1.1.18), glutaminil-tRNKGln se formira posredstvom dva enzima.
Reference
uredi- ↑ Horiuchi, K.Y., Harpel, M.R., Shen, L., Luo, Y., Rogers, K.C. and Copeland, R.A. (2001). „Mechanistic studies of reaction coupling in Glu-tRNAGln amidotransferase”. Biochemistry 40: 6450-6457. PMID 11371208.
- ↑ Curnow, A.W., Tumbula, D.L., Pelaschier, J.T., Min, B. and Söll, D. (1998). „Glutamyl-tRNAGln amidotransferase in Deinococcus radiodurans may be confined to asparagine biosynthesis”. Proc. Natl. Acad. Sci. USA 95: 12838-12843. PMID 9789001.
- ↑ Ibba, M. and Söll, D. (2000). „Aminoacyl-tRNA synthesis”. Annu. Rev. Biochem. 69: 617-650. PMID 10966471.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.