Glutamat formiminotransferaza
Glutamat formiminotransferaza (EC 2.1.2.5, glutamatna formiltransferaza, formiminoglutaminsko kiselinska transferaza, formiminoglutaminska formiminotransferaza, glutamatna formiminotransferaza) je enzim sa sistematskim imenom 5-formimidoiltetrahidrofolat:L-glutamat N-formimidoiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glutamat formiminotransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.1.2.5 | ||||||||
| CAS broj | 9032-83-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 5-formimidoiltetrahidrofolat + L-glutamat tetrahidrofolat + N-formimidoil-L-glutamat
Ovaj enzim je piridoksal-fosfatni protein. On takođe katalizuje formilni transfer sa 5-formiltetrahidrofolata na L-glutamat.
Reference
uredi- ↑ Miller, A. and Waelsch, H. (1957). „Formimino transfer from formamidinoglutaric acid to tetrahydrofolic acid”. J. Biol. Chem. 228: 397-417. PMID 13475327.
- ↑ Silverman, M., Keresztesy, J.C., Koval, G.J. and Gardiner, R.C. (1957). „Citrovorium factor and the synthesis of formylglutamic acid”. J. Biol. Chem. 226: 83-94. PMID 13428739.
- ↑ Tabor, H. and Wyngarden, L. (1959). „The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid”. J. Biol. Chem. 234: 1830-1849. PMID 13672973.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.