Glukuronilgalaktozilproteoglikan 4-b-N-acetilgalaktozaminiltransferaza
Glukuronilgalaktozilproteoglikan 4-b-N-acetilgalaktozaminiltransferaza (EC 2.4.1.174, N-acetilgalaktozaminiltransferaza I, glukuronilgalaktozilproteoglikan beta-1,4-N-acetilgalaktozaminiltransferaza, uridin difosfoacetilgalaktozamin-hondroitin acetilgalaktozaminiltransferaza I, UDP-N-acetil-D-galaktozamin:D-glukuronil-1,3-beta-D-galaktozil-proteoglikan beta-1,4-N-acetilgalaktozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-galaktozamin:D-glukuronil-(1->3)-beta-D-galaktozil-proteoglikan 4-beta-N-acetilgalaktozaminiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glukuronilgalaktozilproteoglikan 4-b-N-acetilgalaktozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.174 | ||||||||
| CAS broj | 96189-39-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-N-acetil-D-galaktozamin + beta-D-glukuronil-(1->3)-D-galaktozil-proteoglikan UDP + N-acetil-D-galaktozaminil-(1->4)-beta-D-glukuronil-(1->3)-beta-D-galaktozilproteoglikan
Za dejstvo ovog enzima je neophodan Mn2+.
Reference
uredi- ↑ Rohrmann, K., Niemann, R. and Buddecke, E. (1985). „Two N-acetylgalactosaminyltransferases are involved in the biosynthesis of chondroitin sulfate”. Eur. J. Biochem. 148: 463-469. PMID 3922754.
- ↑ Uyama, T., Kitagawa, H., Tamura, J.-i. and Sugahara, K. (2002). „Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate”. J. Biol. Chem. 277: 8841-8846. PMID 11788602.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.