Glukozilglicerat sintaza
Glukozilglicerat sintaza (EC 2.4.1.268, Ggs (gen)) je enzim sa sistematskim imenom ADP-glukoza:D-glicerat 2-alfa-D-glukoziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glukozilglicerat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.268 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ADP-glukoza + D-glicerat 2-O-(alfa-D-glukopiranozil)-D-glicerat + ADP
Persephonella marina poseduje dva enzimska sistema sintezu glukozilglicerata. Privi je jednostupni put u kome glukozilglicerat sintaza katalizuje sintezu 2-O-(alfa-D-glukopiranozil)-D-glicerata iz ADP-glukoze i D-glicerata. Drugi sistem se sastoji od dva stupnja, u kojima EC 2.4.1.266 (glukozil-3-fosfoglicerat sintaza) katalizuje konverziju NDP-glukoze i 3-fosfo-D-glicerata u 2-O-(alfa-D-glukopiranozil)-3-fosfo-D-glicerat, koji se zatim konvertuje u 2-O-(alfa-D-glukopiranozil)-D-glicerat posredstvome enzima EC 3.1.3.85 (glukozil-3-fosfoglicerat fosfataze).
Reference uredi
- ↑ Fernandes, C., Empadinhas, N. and da Costa, M.S. (2007). „Single-step pathway for synthesis of glucosylglycerate in Persephonella marina”. J. Bacteriol. 189: 4014-4019. PMID 17369297.
- ↑ Fernandes, C., Mendes, V., Costa, J., Empadinhas, N., Jorge, C., Lamosa, P., Santos, H. and da Costa, M.S. (2010). „Two alternative pathways for the synthesis of the rare compatible solute mannosylglucosylglycerate in Petrotoga mobilis”. J. Bacteriol. 192: 1624-1633. PMID 20061481.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.